Can eyelash serum change your eye colour? Evidence about iris pigmentation is ingredient-specific. The LATISSE prescribing information describes increased brown iris pigmentation with bimatoprost. ANSES separately reported one likely-linked case involving an eyelash serum containing isopropyl cloprostenate. These sources do not establish how often cosmetic lash serums cause this effect or show that every prostaglandin analogue has the same effect.
What the evidence says
LATISSE is a bimatoprost prescription medicine. Its US prescribing information says increased brown iris pigmentation has occurred and is likely to be permanent; it also says the long-term effects are not known. These statements are specific to bimatoprost, not a frequency estimate for cosmetic lash serums. Read the LATISSE label.
France’s ANSES described one case in which it assessed a likely causal link between use of an eyelash serum and reported iris-colour change and periorbital fat loss. The serum contained, among other ingredients, isopropyl cloprostenate; ANSES said the ingredient may have caused the effects. One case report cannot show how often a reaction occurs. Read the ANSES bulletin.
A 2026 SCCS opinion summarises human study material submitted by applicants for finished eyelash products containing isopropyl cloprostenate. One applicant presentation reported no statistically significant visible iris-colour difference on an RGB scale after eight months in a 120-subject study. Elsewhere, SCCS notes that submitted clinical-study results indicated ocular pigmentation changes and reduced periorbital volume. SCCS states it does not take human studies of finished products into account in its safety assessment. These qualified, applicant-submitted summaries do not establish a population-level rate for cosmetic lash serums. Read the SCCS opinion.
How to check a lash serum
Read the full ingredient list (INCI) on the packaging or the brand’s current product page. Bimatoprost and isopropyl cloprostenate are two ingredients discussed in the sources above. If you are unsure about an ingredient name, ask the brand or an eye-care professional; do not assume that every ingredient in the same broad family has the same evidence or effect.
LashOriginals Lash Serum ingredient list
The current published INCI for LashOriginals Lash Serum does not list bimatoprost or isopropyl cloprostenate. This describes the published ingredient list only; it is not a guarantee of individual suitability or zero risk. Review the complete current ingredient list and follow the product directions.
If you notice an eye-area change
If you notice a change in iris appearance or another eye-area concern while using a lash product, stop using it and seek advice from an optometrist or ophthalmologist. Take the packaging or a copy of the ingredient list to your appointment.
FAQ
Can eyelash serum change eye colour?
Bimatoprost labelling describes increased brown iris pigmentation, and ANSES reported one likely-linked case involving a lash serum with isopropyl cloprostenate. Available sources do not establish a rate for cosmetic lash serums or the same effect across all prostaglandin analogues.
Is an iris colour change permanent?
The LATISSE label says increased brown iris pigmentation with bimatoprost is likely to be permanent; it also says long-term effects are not known. That statement should not be applied automatically to every lash-serum ingredient.
Does LashOriginals Lash Serum list bimatoprost or isopropyl cloprostenate?
The current published INCI does not list those ingredients. This is formula information from the published list, not a guarantee of individual suitability or zero risk.
How can I check a product?
Use the full current INCI on the packaging or product page. If you cannot identify an ingredient, ask the brand or an eye-care professional.
Sources
- LATISSE (bimatoprost) prescribing information
- ANSES cosmetovigilance bulletin, December 2025
- European Commission SCCS opinion SCCS/1680/25
- LashOriginals Lash Serum published ingredient list